Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic.
Identifieur interne : 000170 ( Main/Exploration ); précédent : 000169; suivant : 000171Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic.
Auteurs : André Schulz [Allemagne] ; Jan Hendrik Matthey [Allemagne] ; Claus Vögele [Luxembourg (pays)] ; Violetta Schaan [Luxembourg (pays)] ; Hartmut Sch Chinger [Allemagne] ; Julia Adler [Allemagne] ; Manfred E. Beutel [Allemagne] ; Matthias Michal [Allemagne]Source :
- Psychiatry research [ 1872-7123 ] ; 2016.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adult, Baroreflex (physiology), Brain (physiopathology), Brain Stem (physiopathology), Depersonalization (physiopathology), Evoked Potentials (physiology), Female, Heart (physiopathology), Heart Rate (physiology), Humans, Male, Reflex, Startle (physiology), Visceral Afferents (physiopathology).
- MESH :
- physiology : Baroreflex, Evoked Potentials, Heart Rate, Reflex, Startle.
- physiopathology : Brain, Brain Stem, Depersonalization, Heart, Visceral Afferents.
- Acoustic Stimulation, Adult, Female, Humans, Male.
Abstract
Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105dB(A), 50ms) elicited 0, 100, 200, 300, 400 and 500ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300ms than at 0 and 400ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.
DOI: 10.1016/j.psychres.2016.03.051
PubMed: 27078753
Affiliations:
- Allemagne, Luxembourg (pays)
- Rhénanie-Palatinat
- Luxembourg, Mayence, Trèves (Allemagne)
- Université de Trèves, Université du Luxembourg
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Le document en format XML
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Electronic address: manfred.beutel@unimedizin-mainz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. 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Electronic address: andre.schulz@uni.lu.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg; Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier</wicri:regionArea><wicri:noRegion>54290 Trier</wicri:noRegion><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author><author><name sortKey="Matthey, Jan Hendrik" sort="Matthey, Jan Hendrik" uniqKey="Matthey J" first="Jan Hendrik" last="Matthey">Jan Hendrik Matthey</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. 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Electronic address: claus.voegele@uni.lu.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette</wicri:regionArea><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author><author><name sortKey="Schaan, Violetta" sort="Schaan, Violetta" uniqKey="Schaan V" first="Violetta" last="Schaan">Violetta Schaan</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: violetta.schaan@uni.lu.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette</wicri:regionArea><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation wicri:level="4"><nlm:affiliation>Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. Electronic address: schaechi@uni-trier.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier</wicri:regionArea><wicri:noRegion>54290 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Adler, Julia" sort="Adler, Julia" uniqKey="Adler J" first="Julia" last="Adler">Julia Adler</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: julia.adler@uni-mainz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Beutel, Manfred E" sort="Beutel, Manfred E" uniqKey="Beutel M" first="Manfred E" last="Beutel">Manfred E. Beutel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: manfred.beutel@unimedizin-mainz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: matthias.michal@unimedizin-mainz.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Baroreflex (physiology)</term><term>Brain (physiopathology)</term><term>Brain Stem (physiopathology)</term><term>Depersonalization (physiopathology)</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Heart (physiopathology)</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Male</term><term>Reflex, Startle (physiology)</term><term>Visceral Afferents (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Baroreflex</term><term>Evoked Potentials</term><term>Heart Rate</term><term>Reflex, Startle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Brain Stem</term><term>Depersonalization</term><term>Heart</term><term>Visceral Afferents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105dB(A), 50ms) elicited 0, 100, 200, 300, 400 and 500ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300ms than at 0 and 400ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Luxembourg (pays)</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Luxembourg</li><li>Mayence</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li><li>Université du Luxembourg</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name></noRegion><name sortKey="Adler, Julia" sort="Adler, Julia" uniqKey="Adler J" first="Julia" last="Adler">Julia Adler</name><name sortKey="Beutel, Manfred E" sort="Beutel, Manfred E" uniqKey="Beutel M" first="Manfred E" last="Beutel">Manfred E. Beutel</name><name sortKey="Matthey, Jan Hendrik" sort="Matthey, Jan Hendrik" uniqKey="Matthey J" first="Jan Hendrik" last="Matthey">Jan Hendrik Matthey</name><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></country><country name="Luxembourg (pays)"><noRegion><name sortKey="Vogele, Claus" sort="Vogele, Claus" uniqKey="Vogele C" first="Claus" last="Vögele">Claus Vögele</name></noRegion><name sortKey="Schaan, Violetta" sort="Schaan, Violetta" uniqKey="Schaan V" first="Violetta" last="Schaan">Violetta Schaan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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